雷美替安 (Rozerem)

概览

Ramelteon is a melatonin receptor agonist used to treat insomnia.

作用机制

Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT and MT receptors, and lower selectivity for the MT receptor. Melatonin production is concurrent with nocturnal sleep, meaning that an increase in melatonin levels is related to the onset of self-reported sleepiness and an increase in sleep propensity. MT receptors are believed to be responsible for regulation of sleepiness and facilitation of sleep onset, and MT receptors are believed to mediate phase-shifting effects of melatonin on the circadian rhythm. While MT and MT receptors are associated with the sleep-wake cycle, MT has a completely different profile, and therefore is not likely to be involved in the sleep-wake cycle. Remelteon has no appreciable affinity for the gamma-aminobutyric acid (GABA) receptor complex or receptors that bind neuropeptides, cytokines, serotonin, dopamine, norepinephrine, acetylcholine, or opiates.

适应症

用于失眠症，特别适用于治疗难以入睡型失眠症。

• Insomnia