结合雌激素 (Congest, Duavee, Duavive +3)

概览

Conjugated estrogens is a mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis.

作用机制

The conjugated estrogens, equally to the normal physiological estrogen, work by agonistically binding to the estrogen receptors alpha and beta. The estrogen receptors vary in quantity and proportion according to the tissues and hence, the activity of this conjugated estrogens is very variable. The activity made by the conjugated estrogens is driven by the increase in the synthesis of DNA, RNA and various proteins in responsive tissues which in order will reduce the release of gonadotropin-releasing hormone, follicle-stimulating hormone and leuteinizing hormone. The specific mechanism of action cannot be described only in terms of total estrogenic action as the pharmacokinetic profile, the tissue specificity and the tissue metabolism is different for each component of the product.

适应症

The conjugated estrogens are indicated for several different conditions including:

• Abnormal Uterine Bleeding
• Atrophic Vaginitis
• Atrophy of vulva
• Kraurosis Vulvae
• Menopause
• Metastatic Breast Cancer
• Moderate to Severe Vasomotor Symptoms
• Osteoporosis
• Androgen-dependent tumor Advanced Prostate Carcinoma
• Hypoestrogenism
• Moderate Dyspareunia
• Moderate Vulvar and Vaginal Atrophy