Artesunate
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Artesunate is artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
Artesunate is artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
Artesunate is metabolized to the active DHA. the endoperoxide bridge of DHA reacts with heme, generating free radicals which inhibit protein and nucleic acid synthesis of the Plasmodium parasites during all erythrocytic stages. Reactions with these free radicals can also lead to alkylation of parasitic proteins such as a calcium adenosine triphosphatase and EXP1, a glutathione S-transferase.
Artesunate is indicated for the initial treatment of severe malaria in adult and pediatric patients.
