奥芬那君 (Norgesic, Norgesic Forte, Orfenace +1)

概览

Orphenadrine is a muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.

作用机制

Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect.

适应症

用于治疗帕金森病和吩噻嗪类药物引起的锥体外系症状，但对迟发性运动障碍无效。用于治疗急性肌骨骼疼痛

• Back Pain Lower Back
• Fever
• Menstrual Distress (Dysmenorrhea)
• Mild pain
• Muscle Spasms
• Mild Musculoskeletal Disorder
• Mild to moderate pain
• Moderate Musculoskeletal Disorder
• Moderate Pain