西司他丁 (Primaxin, Recarbrio)

概览

Cilastatin is a renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.

作用机制

Cilastatin is a renal dehydropeptidase-I inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to block the metabolism of imipenem.

适应症

Cilastatin is indicated, in combination with imipenem with or without relebactam, for the treatment of bacterial infections including respiratory, skin, bone, gynecologic, urinary tract, and intra-abdominal as well as septicemia and endocarditis.

• Bacterial Septicemia
• Bone and Joint Infections
• Complicated Intra-Abdominal Infections (cIAIs)
• Complicated Urinary Tract Infection
• Endocarditis caused by staphylococcus aureus
• Gynecological Infection
• Intraabdominal Infections
• Lower respiratory tract infection bacterial
• Neutropenic Fever
• Pyelonephritis
• Skin and Subcutaneous Tissue Bacterial Infections
• Surgical Site Infections