去铁酮 (Ferriprox, Deferiprone Lipomed)

概览

Deferiprone is an iron chelator used to treat patients with transfusional iron overload caused by thalassemia syndromes.

作用机制

Deferiprone is an iron chelator that binds to ferric ions (iron III) and forms a 3:1 (deferiprone:iron) stable complex and is then eliminated in the urine. Deferiprone is more selective for iron in which other metals such as zinc, copper, and aluminum have a lower affinity for deferiprone.

适应症

Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.

• Transfusional Iron Overload