Crisaborole
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Crisaborole is a non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.
Crisaborole is a non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.
Inhibition of PDE4 by crisaborole leads to elevated levels of cyclic adenosine monophosphate (cAMP). Increased intracellular levels of cAMP inhibit the NF-kB pathway and suppress the release of pro-inflammatory mediators such as TNF-alfa and various interleukins that play a causative role in psoriasis and atopic dermatitis. Suppression of downstream effects in different cell types may explain the therapeutic role of crisaborole in immune-mediated skin diseases.
Intended for the topical treatment of mild to moderate atopic dermatitis in patients 2 years of age and older.
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