Phenylpropanolamine

概览

Phenylpropanolamine is a sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.

作用机制

Phenylpropanolamine acts directly on alpha- and, to a lesser degree, beta-adrenergic receptors in the mucosa of the respiratory tract. Stimulation of alpha-adrenergic receptors produces vasoconstriction, reduces tissue hyperemia, edema, and nasal congestion, and increases nasal airway patency. PPA indirectly stimulates beta-receptors, producing tachycardia and a positive inotropic effect.

适应症

For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.

• Allergy-Induced Respiratory Symptoms
• Bronchitis
• Common Cold
• Cough
• Nasal Congestion
• Rhinorrhoea
• Excess mucus or phlegm