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Pentolinium is a nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
Pentolinium is a nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
Pentolinium binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.
Used to produce controlled hypotension during surgical procedures and in hypertensive crises.
