依达赛珠单抗 (Praxbind)

概览

Idarucizumab is an antibody that binds dabigatran for the reversal of anticoagulant effects of dabigatran.

作用机制

Idarucizumab is a specific reversal agent for dabigatran. It is a humanized monoclonal antibody fragment (Fab) that binds to dabigatran and its acylglucuronide metabolites with higher affinity than the binding affinity of dabigatran to thrombin, neutralizing their anticoagulant effect.

适应症

For use in patients treated with Dabigatran when reversal of the anticoagulant effects of dabigatran is needed for emergency surgery/urgent procedures and in life-threatening or uncontrolled bleeding.

• Anticoagulant effects of dabigatran