凝血酶 (Thrombin-jmi)

概览

Thrombin is a coagulation factor used to stop bleeding during surgery.

作用机制

Bovine thrombin requires no intermediate physiological agent for its action . It activates platelets and catalyzes the conversion of fibrinogen to fibrin, which are essential steps for clot formation . Failure to clot blood occurs in the case where the primary clotting defect is the absence of fibrinogen itself . The speed with which the bovine thrombin clots blood is dependent upon the concentration of both the bovine thrombin and the fibrinogen present .

适应症

Bovine thrombin is a topical thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (like suture, ligature, or cautery) is ineffective or impractical . Additionally, topical bovine thrombin can also be used in combination with an absorbable gelatin sponge, USP .

• Refractory to surgical techniques Bleeding