Pancrelipase protease (Cotazym, Creon, Pancrease MT +4)

概览

Pancrelipase protease is a lipase used to treat pancreatic exocrine insufficiency.

作用机制

Pancrelipase protease acts on the peptide bonds within the proteins. The two constituents of the pancrelipase protease, trypsin, and chymotrypsin, are grouped under the family of serine proteases. Trypsin acts on lysine and arginine residues while chymotrypsin acts in hydrophobic residues such as tryptophan, tyrosine and phenylalanine. Both constituents present a catalytic site in the S1 binding pocket formed by a triad of serine, histidine and aspartate.

适应症

Please refer to Pancrelipase.

• Exocrine Pancreatic Insufficiency