头孢唑林

概览

Cefazolin is a broad-spectrum cephalosporin antibiotic mainly used for the treatment of skin bacterial infections and other moderate to severe bacterial infections in the lung, bone, joint, stomach, blood, heart valve, and urinary tract.

作用机制

In vitro tests demonstrate that the bactericidal action of cephalosporins results from inhibition of cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

适应症

Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.

• Bacterial Septicemia caused by susceptible Bacterial Infections
• Biliary tract infection bacterial caused by susceptible Bacterial Infections
• Bone and Joint Infections caused by susceptible Bacterial Infections
• Catheter-related Bloodstream Infection (CRBSI) NOS
• Community Acquired Pneumonia (CAP)
• Endocarditis caused by susceptible Bacterial Infections
• Genital infection caused by susceptible Bacterial Infections
• Osteoarticular Infections
• Postoperative Infections
• Respiratory Tract Infection Bacterial caused by susceptible Bacterial Infections
• Skin and Soft Tissue Infections (SSTIs)
• Skin and Subcutaneous Tissue Infection caused by susceptible Bacterial Infections