双环胺 (Bentyl)

概览

Dicyclomine is an antimuscarinic agent used to treat IBS.

作用机制

Dicyclomine achieves its action partially through direct antimuscarinic activity of the M1, M3, and M2 receptors; and partially through antagonism of bradykinin and histamine. Dicyclomine non-competitively inhibits the action of bradykinin and histamine, resulting in direct action on the smooth muscle, and decreased strength of contractions seen in spasms of the ileum.

适应症

Dicyclomine is indicated for the treatment of functional bowel disorder and irritable bowel syndrome.

• Bowel; Functional Syndrome
• Irritable Bowel Syndrome (IBS)
• Gastrointestinal cramps caused by Gas