Creatine
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Creatine is an endogenous amino acid derivative synthesized from L-arginine, glycine and L-methionine, and is also widely used as a dietary supplement. It plays a critical role in cellular energy metabolism by serving as a phosphate acceptor to regenerate ATP via the creatine kinase/phosphocreatine system. Beyond its established roles in muscle energetics and neuroprotection, preclinical research has identified that creatine fuels dendritic cells and killer T cells, enhancing anti-tumor immune responses.
Creatine is an endogenous amino acid derivative synthesized from L-arginine, glycine and L-methionine, and is also widely used as a dietary supplement. It plays a critical role in cellular energy metabolism by serving as a phosphate acceptor to regenerate ATP via the creatine kinase/phosphocreatine system. Beyond its established roles in muscle energetics and neuroprotection, preclinical research has identified that creatine fuels dendritic cells and killer T cells, enhancing anti-tumor immune responses.
In the muscles, a fraction of the total creatine binds to phosphate - forming creatine phosphate. The reaction is catalysed by creatine kinase, and the result is phosphocreatine (PCr). Phosphocreatine binds with adenosine diphosphate to convert it back to ATP (adenosine triphosphate), an important cellular energy source for short term ATP needs prior to oxidative phosphorylation.
For nutritional supplementation, also for treating dietary shortage or imbalance.
