Aizen Therapeutics Inks Multi-Program Deal to Advance Oral Biologics with DaX AI Platform
核心洞察
Aizen Therapeutics (搜索) announced a multi-program collaboration with a San Diego-based public biotech to design oral peptide therapeutics using its DaX foundation model.
The agreement provides Aizen with several million dollars in initial revenue and up to $100 million in milestones for each nominated target.
The collaboration targets validated biological targets in immunology and neurology indications, aiming to deliver improved therapeutic index and reduced systemic toxicity in a pill.
Aizen Therapeutics (搜索), an AI-native biotechnology company focused on building oral biologics, announced a multi-program collaboration with a San Diego-based, public biotech to design oral peptide therapeutics using its DaX foundation model. The agreement, disclosed on Aug. 15, 2026, provides Aizen with several million dollars in initial revenue and up to $100 million in milestones for each nominated target.
"Oral biologics represent a new frontier in drug development. We are focused on designing oral peptides for validated biological targets that can deliver an improved therapeutic index, reduced systemic toxicity, and enhanced target engagement in a pill," said Ajay Kshatriya, Chief Executive Officer and co-founder of Aizen Therapeutics (搜索). "We are excited to collaborate with a world-class partner to develop proof of activity with our DaX platform for well-known disease-relevant targets in immunology and neurology indications."
The DaX Platform and Its Origins
Aizen was spun out from Caltech (搜索), with a first-in-class computational design model for peptides. The DaX platform has been trained on millions of uniquely annotated molecules and receptors and explores the non-canonical amino acid (ncAA) peptide chemical space at ten times the scale of traditional ncAA discovery methods.
"With technical challenges in data scarcity and chemical complexity, de novo peptide design is the frontier of Drug Discovery AI," said David Van Valen, MD, PhD, Aizen Scientific Founder and Caltech (搜索) Professor. "This collaboration represents a meaningful step for the field, pairing AI peptide design with a world-class biopharma category leader to advance molecules into medicines."
Strategic Positioning in Oral Biologics
Aizen is an AI-native biotechnology company pioneering oral peptides to transform the lives of patients and families burdened by chronic immune disorders. Powered by DaX—a foundational AI platform developed by Caltech (搜索) faculty—the company designs de novo peptides that transcend natural biology through the expansive chemical landscape of non-canonical amino acids (ncAA).
Headquartered in San Diego and venture-backed, Aizen is advancing a proprietary pipeline of gut-restricted and systemic oral biologics. Simultaneously, the company collaborates with global biopharma to deploy its platform against high-value technical frontiers, synthesizing the precision of antibodies with the stability and oral delivery of small molecules.