Cell-Based Therapy Shows Functional Improvement in Sjögren's Syndrome Patient with Severe Neurological Complications
核心洞察
A 28-year-old woman with Sjögren's syndrome (搜索)-associated ganglionopathy who was wheelchair-dependent for nearly four years showed mobility improvement within 15 days of cell-based therapy at StemRx Hospital in Navi Mumbai.
The personalized treatment program included cell-based therapy, exosome-based treatment, mitochondrial therapy, physiotherapy, rehabilitation, and nutritional support.
The patient reported reduced oral dryness, easier swallowing, less back pain and muscle stiffness, and regained ability to stand and walk with stick support.
A 28-year-old woman from Kolkata who had been wheelchair-dependent for nearly four years due to severe neurological complications of Sjögren's syndrome (搜索) has demonstrated encouraging functional improvement following a personalized cell-based therapy and rehabilitation program at StemRx Hospital & Research Centre (搜索) in Navi Mumbai.
Taniya Modak Paik's symptoms began in 2018 with an unusual pulling sensation while walking. Her condition gradually worsened, manifesting as severe dryness of the eyes and mouth, loss of taste, muscle weakness, and progressive neurological problems. A muscle biopsy in December 2023 confirmed autoimmune myositis, and she was subsequently diagnosed with Sjögren's syndrome (搜索), which explained her constellation of neurological symptoms.
Despite undergoing plasmapheresis in May 2024 and receiving monoclonal antibody therapy and Rituximab infusions in 2025, her mobility continued to deteriorate, and she became wheelchair-dependent.
Personalized Regenerative Medicine Approach
After consulting Dr. Pradeep Mahajan, a regenerative medicine expert and founder of StemRx Hospital & Research Centre (搜索), the patient underwent an individualized treatment program tailored to her neurological condition and functional limitations. The program comprised cell-based therapy, targeted exosome-based treatment, mitochondrial therapy, physiotherapy, rehabilitation, and nutritional support.
"Sjögren's syndrome (搜索) can, in some patients, affect the nervous system and cause ganglionopathy, leading to sensory loss, balance problems, stiffness and difficulty walking," said Dr. Mahajan. He emphasized that early diagnosis, appropriate treatment, and long-term rehabilitation are important for managing such complications.
Rapid Functional Gains
According to the hospital, within 15 days of treatment, Taniya reported reduced oral dryness and gum bleeding, easier swallowing, less back pain and muscle stiffness, and improved mobility. She was able to get up from a chair more easily and walk with the support of a stick.
Taniya said the improvement in her ability to stand and walk with support restored her confidence and gave her renewed hope after years of progressive disability and loss of independence. She has been discharged with advice to continue regular physiotherapy, follow-up, and continued medical supervision.
Cautious Interpretation Warranted
Sjögren's syndrome (搜索) is an autoimmune disorder in which the immune system attacks the body's moisture-producing glands, primarily causing dry eyes and mouth. It can also affect other parts of the body, causing fatigue, joint and muscle pain, numbness, weakness, and in severe cases, complications involving the lungs, kidneys, and other organs. Doctors estimate that it affects approximately 0.1% to 1% of the population.
Experts have stated that the reported improvement is based on an individual case and does not establish that cell-based therapy can cure Sjögren's syndrome (搜索) or its neurological complications. Longer-term follow-up and clinical evidence are needed to assess the durability and effectiveness of such treatment.