Mosaic Therapeutics appoints Dr Allison Jeynes as Chair of the Board ahead of clinical-stage transition
核心洞察
Mosaic Therapeutics (搜索) has appointed Dr Allison Jeynes, a UK-trained oncologist with over three decades of drug development experience, as Chair of the Board.
Jeynes previously led Avillion (搜索) to a 100% success rate from Phase 3 through FDA approval and contributed to 20 drug approvals across her career.
She succeeds Dr Edward Hodgkin, who remains a Non-Executive Director, as Mosaic advances toward becoming a clinical-stage organization.
Mosaic Therapeutics (搜索), Ltd, an oncology therapeutics company developing novel, targeted drug combinations across a range of haematological and solid cancers, has announced the appointment of Dr Allison Jeynes as Chair of the Board. The appointment supports the Company's next phase of growth and advancement toward clinical development. Allison succeeds Dr Edward Hodgkin, who remains a Non-Executive Director of the Board.
A seasoned oncology leader
Allison is a UK-trained oncologist and highly-experienced life sciences leader, bringing over three decades of drug development and executive experience to Mosaic Therapeutics (搜索). As CEO of Avillion (搜索), a clinical development company, for the last 13 years, she led global teams to achieve a 100% success rate from Phase 3 development through to FDA approval for multiple programs spanning oncology, immunology and respiratory medicine. She also raised funds of around $400M as founder and CEO.
Across her career, Allison has contributed to 20 drug approvals, engaging with the FDA, MHRA and EMA, and has previously held senior positions at Wyeth, Bristol Myers Squibb and Novartis. She began her clinical career as a medical oncologist at the Royal Marsden Hospital, UK, and obtained her medical degree (MB ChB) from the University of Sheffield.
Board succession and strategic direction
Edward Hodgkin, Non-Executive Director and Managing Partner at Syncona Investment Management Limited, worked closely with the Board and management to lead the succession process. He will continue to serve as a Non-Executive Director, supporting Allison and the Board as the Company builds on its momentum and enters its next phase of development.
"We are thrilled to welcome Allison as Chair of the Board as we advance into a clinical-stage organisation," said Thomas Fuchs, CEO, Mosaic Therapeutics (搜索). "Her exceptional track record of leading and financing successful drug development programs brings significant strategic and operating depth to our Board, and optimally positions Mosaic to realise the full potential of our pipeline."
Allison Jeynes, Chair of the Board, Mosaic Therapeutics (搜索), commented: "Mosaic has built a strong scientific and organisational foundation, and I am delighted to serve as Chair at such a pivotal moment in the Company's evolution as they progress into the clinic. Mosaic's pipeline of targeted combination programs has real potential to deliver transformational new medicines for patients with few treatment options today. I look forward to working closely with Tom, the Board and the team to guide the Company to its next inflection point."
The ASTX295 pipeline
Mosaic Therapeutics (搜索) is developing ASTX295, a highly potent, clinical-stage, bone marrow-sparing MDM2 (搜索) antagonist that is designed to be best-in-class, for use in combination across a range of haematological and solid cancers. The Company's mission is to tackle cancers with substantial unmet need and few targeted treatment options, by reinventing the traditional approach to discovering and developing novel combination medicines.
Born out of pioneering research at the Wellcome Sanger Institute, in collaboration with the Netherlands Cancer Institute, Mosaic has active programmes across a variety of oncology indications. The Company's pipeline of combination programmes is anchored by ASTX295, in-licensed from Astex Pharmaceuticals (搜索) in April 2025. Mosaic's first clinical combination study is expected to commence in mid-2027.
Allison currently serves on the boards of Anaveon and Uniquity Bio, is Chair of Siolta Therapeutics, and holds senior advisory roles with Blackstone Life Sciences and Recordati.