相关临床试验
5
0 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1930
已完成
3
60.0%
招募中
1
20.0%
撤回
1
20.0%
暂无批准数据
- Pfizer and Valneva have completed a 9,000-participant Lyme vaccine trial showing 73.2 to 74.8 percent efficacy with no safety concerns, and are preparing an FDA submission. - The vaccine missed its primary statistical goal, though Pfizer called the reduction in infections clinically meaningful; results will be presented at a scientific congress. - A March court injunction bars the 13 ACIP members appointed in 2025 from meeting or issuing new vaccine recommendations, leaving the Lyme rollout pathway undefined. - Without ACIP guidance, insurance coverage and Vaccines for Children Program access are uncertain, and medical societies are issuing patchwork recommendations in its place.
- Human milk oligosaccharides (HMOs), the third most abundant solid in breast milk, are indigestible by infants and instead feed beneficial gut bacteria such as Bifidobacterium species to shape the developing microbiome. - Breast milk delivers immune factors including secretory IgA, lactoferrin and lysozyme, which help explain why breastfed infants experience fewer gastrointestinal infections, especially in the first year of life. - The PROBIT randomized trial found fewer gastrointestinal infections and less atopic eczema in infancy, but no clear reduction in obesity and mixed cognitive findings by age 16. - Breast milk provides DHA, a key structural component of the developing brain and retina, and breastfeeding is associated with improved cognitive development and greater myelination in imaging studies.
- California has confirmed 52 measles cases in 2026, more than double the number reported in 2025, with most cases occurring in unvaccinated individuals. - Nearly 2,300 measles cases were reported across the United States in 2025, the highest annual total since 2000, with 2026 cases on pace to surpass that figure. - CDPH Director Dr. Erica Pan reaffirmed confidence in the safety and effectiveness of the MMR vaccine, which California requires for school and childcare entry. - California maintains more than 95% MMR vaccine coverage among kindergarteners, a level that can prevent large measles outbreaks but still requires continued vaccination.
- MedPAC data show nearly all Medicare beneficiaries have a primary care provider, with over 75% able to see their PCP within two weeks, challenging the narrative of a primary care access crisis. - U.S. life expectancy gaps with peer nations are driven primarily by external causes—drugs, alcohol, suicide, homicide, and traffic accidents—rather than inadequate primary care access. - The budget-neutral Medicare physician fee schedule creates a zero-sum competition between primary care and specialty care, where declining specialist access metrics have received far less attention. - Physician leaders from the AAFP, ACP, and AAP argue that primary care and specialty care are complementary, not competing, and call for comprehensive payment reform that strengthens both.
- Influenza vaccine effectiveness in adults 65 and older can wane by approximately 10% every 30 days post-vaccination, prompting calls for optimized vaccination timing in early-to-mid-October. - Co-circulation of influenza, RSV, SARS-CoV-2, and bacterial pathogens like pertussis demands sustained diagnostic surveillance and focused treatment strategies across all age groups. - Vaccine hesitancy among both the public and healthcare practitioners is identified as the most critical barrier to respiratory disease prevention, requiring renewed education and trust-building efforts. - mRNA-based combination vaccines and next-generation monoclonal antibodies are highlighted as the most promising innovations to transform respiratory medicine over the coming decade.
- A new JAMA Pediatrics study found egg allergy prevalence in Australian infants fell from 9.2% to 7.6% after 2016 guidelines recommended introducing eggs by 6 months of age. - The proportion of infants introduced to eggs by 6 months more than doubled, from about 25% before guideline changes to 57% afterward. - In infants with early eczema, a known risk factor, egg allergy prevalence dropped even more sharply from 34.6% to 21.9%. - Researchers say similar reductions would be expected in the U.S., where professional bodies also recommend early egg introduction, though U.S. adoption rates remain lower.
- The Trump administration's new Medicaid work requirement rule, effective January 2027, mandates 80 hours of monthly documented work or equivalent activity for adults aged 19–64 in expansion states. - The interim final rule narrowly defines exemptions, requiring that a condition "actively interferes" with work ability, leaving early-stage cancer patients and people with HIV who can technically work unprotected. - Arkansas's earlier experiment with work requirements resulted in over 18,000 people losing coverage in seven months with no increase in employment; 64% of those who lost coverage delayed needed medications. - The Congressional Budget Office projects approximately 4.8–5 million people will lose Medicaid coverage under the new requirements, part of a $900 billion Medicaid cut.
- Memorial Health becomes one of only three to four hospitals nationwide participating in a clinical trial evaluating the second-generation Entarik feeding tube system for premature infants. - The FDA-cleared device features built-in sensors for precise stomach placement and continuous position monitoring, reducing injury risks and eliminating the need for frequent X-rays. - Early results show positive outcomes in multiple babies, with one mother reporting "almost instant improvement" in her twins' feeding compared to traditional methods. - The technology provides real-time digestive activity tracking to help NICU teams better manage feeding schedules and respond quickly to complications.
- The FDA plans to present data at next week's CDC Advisory Committee on Immunization Practices meeting claiming to link COVID-19 vaccines to 25 deaths in children, based on analysis of VAERS database reports. - Health experts and former FDA officials are criticizing the approach, noting that VAERS reports are unverified and cannot establish causation between vaccines and deaths without additional investigation. - The presentation comes amid significant changes to the CDC advisory panel, with HHS Secretary Robert F. Kennedy Jr. having replaced all committee members with his own appointees, including known vaccine skeptics. - Current research continues to show COVID-19 vaccines are safe in children, with studies involving over 10 million vaccinated children demonstrating reduced infection and hospitalization rates.
- The Trump administration is reportedly preparing to remove COVID-19 vaccines from the US market "within months," according to Dr. Aseem Malhotra, a close associate of HHS Secretary Robert F. Kennedy Jr. - Kennedy has already implemented significant policy changes including removing routine COVID-19 vaccination recommendations for healthy children and pregnant women from CDC guidelines and scrapping over $500 million in mRNA vaccine funding. - The potential withdrawal is based on skepticism rooted in a 2022 peer-reviewed study claiming 16% higher rates of serious adverse events, though this research has been widely dismissed by the scientific community due to methodological concerns. - Over 750 current and former federal health employees have accused Kennedy of spreading inaccurate health information, with criticism intensifying following a deadly shooting at CDC headquarters by an anti-vaccine individual.
