B. Braun Singapore Pte Ltd.

<p><strong>4.1. Therapeutic indications</strong></p> <p><strong>a. Acute pain management in adults and adolescents (&gt; 12 years of age):</strong></p> <ul class="dash"> <li>Continuous epidural infusion or intermittent bolus administration during postoperative or labour pain</li> <li>Field blocks</li> <li>Continuous peripheral nerve block via a continuous infusion or intermittent bolus injections, e.g. postoperative pain management</li> </ul> <p><em>There are no safety or efficacy data to support the use of ropivacaine administered epidurally for analgesia for longer than 72 hours. Data for peripheral nerve block administered as a continuous peripheral infusion or intermittent injections support the use for up to 48 hours only.</em></p> <p><strong>b. Acute pain management in paediatrics</strong> (for peri- and post-operative pain management):</p> <ul class="dash"> <li>Caudal epidural block in neonates (&gt; 37 weeks gestation and over 2500 g weight), infants and children up to and including 12 years</li> <li>Continuous epidural infusion in infants (&gt; 30 days and over 2500 g weight) and children up to and including 12 years</li> </ul> <p>There are no safety or efficacy data to support the use of ropivacaine administered epidurally for analgesia for longer than 72 hours.</p>

<p><strong>4.1 Therapeutic indications</strong></p> <p><em>Intensive Care Unit Sedation</em></p> <p>Dexmedetomidine is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Dexmedetomidine should be administered by continuous infusion not to exceed 24 hours.</p> <p>Dexmedetomidine has been continuously infused in mechanically ventilated patients prior to extubation, during extubation, and post-extubation. It is not necessary to discontinue Dexetomidine prior to extubation.</p> <p><em>Procedural Sedation</em></p> <p>For sedation of non-intubated adult patients prior to and/or during diagnostic or surgical procedures requiring sedation, i.e. procedural/awake sedation.</p>

<p><strong>4.1 Therapeutic indications</strong></p> <p>Supply of energy, essential fatty acids including omega-3 and omega-6 fatty acids, amino acids, electrolytes and fluids for parenteral nutrition of patients in states of moderate to severe catabolism when oral or enteral nutrition is impossible, insufficient or contraindicated.</p> <p>Nutriflex&reg; Omega Special B. Braun Emulsion for Infusion is indicated in adults.</p>

<p><strong>4.1 Therapeutic indications</strong><br> Ibuprofen B. Braun is indicated in children (&ge; 5 kg body weight), adolescents and adults for the short-term symptomatic treatment of acute moderate pain, and for the short-term symptomatic treatment of fever, when administration by intravenous route is clinically justified, when other routes of administration are not possible.</p>

<p><strong>4.1 Therapeutic indications</strong><br> Takipril is indicated in adults for spinal anaesthesia in <u>short-term surgical procedures (see section 4.2).</u></p>

<p><strong>4.1 Therapeutic indications</strong><br> The ready-to-use solution is indicated for use in patients with acute renal failure requiring continuous haemofiltration.</p>

<p><strong>4.1 Therapeutic indications</strong><br> The ready-to-use solution is indicated for use in patients with acute renal failure requiring continuous haemofiltration.</p>

**4.1 Therapeutic indications** The ready-to-use solution is indicated for use in patients with acute renal failure requiring continuous haemofiltration.

<p><strong>Indications</strong></p> <p><strong>Adults</strong><br> Ondansetron B. Braun 2 mg/ml solution for injection or infusion is indicated for the management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy.<br> Ondansetron B. Braun 2 mg/ml solution for injection or infusion is also indicated for the prevention and treatment of post-operative nausea and vomiting<br> <strong>Paediatric population</strong><br> Ondansetron B. Braun 2 mg/ml solution for injection or infusion is indicated for the management of nausea and vomiting induced by cytotoxic chemotherapy<br> Ondansetron B. Braun 2 mg/ml solution for injection or infusion is also indicated for the prevention and treatment of postoperative nausea and vomiting</p>

<p><strong>4.1 Therapeutic indications</strong><br> Supply of energy, essential fatty acids including omega-3 and omega-6 fatty acids, amino acids, electrolytes and fluids for parenteral nutrition of patients in states of moderate to severe catabolism when oral or enteral nutrition is impossible, insufficient or contraindicated. Nutriflex Omega special is indicated in adults.</p>