Dongguk University

Dongguk University Researchers Develop Electromagnetically Controllable Gene Switch for Remote Gene Therapy

- Researchers at Dongguk University developed an electromagnetic field (EMF)-inducible gene switch enabling fully reversible, safe, and precise remote control of gene expression. - The switch uses the Lgr4 gene promoter and was validated in transgenic mice, showing tunable, localized expression that returns to baseline within 24 hours after stimulation stops. - A genome-wide CRISPR-Cas9 screen identified cytochrome b5 type B (Cyb5b) as the first reported molecular sensor for electromagnetic fields. - The platform demonstrated applications in Alzheimer's disease modeling, reversing aging markers, and restoring serotonin levels to reduce depression-like behaviors in mice.