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- The Federal Circuit reversed the Patent Trial and Appeal Board's obviousness ruling that invalidated Eye Therapies' patent claims for brimonidine-based eye redness treatments. - The court found the Board incorrectly interpreted the claim phrase "consisting essentially of" by ignoring prosecution history that narrowed the patent's scope to exclude other active ingredients. - The ruling strengthens patent protection for brimonidine monotherapy in treating conjunctival hyperemia and establishes important precedent for claim construction based on prosecution history.