相关临床试验
948
318 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
N/A
进行中（未招募）
89
9.4%
已完成
211
22.3%
Enrolling By Invitation
7
0.7%
尚未招募
222
23.4%
招募中
379
40.0%
暂停
2
0.2%
终止
5
0.5%
Unknown
28
3.0%
撤回
5
0.5%
暂无批准数据
- A pilot randomized trial found short-term fasting before and after chemotherapy reduced insulin levels in patients with high-grade serous ovarian cancer, with a mean change of –1.12 µIU/mL vs +9.76 µIU/mL in the free-diet group (P = .01). - Patients in the fasting arm achieved a significantly higher complete/near-complete pathologic response rate at interval cytoreductive surgery (58.8% vs 17.6%; P = .03). - Median progression-free survival was 38 months with short-term fasting compared to 24 months with a free diet (P = .045), with no significant differences in chemotherapy toxicity between groups. - Translational analyses suggested a more favorable immune environment with fasting, including lower immunosuppressive granulocyte and monocyte subsets, supporting larger confirmatory trials.
- Interim clinical data from the EndoZip™ automated endoscopic suturing system demonstrated an average total body weight loss of 11.4% at twelve months in patients with class I and II obesity. - The study evaluated twenty patients with BMI 30-42 kg/m² who also had hypertension and/or type 2 diabetes, showing 54% of hypertensive patients improved blood pressure and 62.5% of diabetic patients demonstrated improved diabetes health conditions. - The minimally invasive procedure demonstrated a favorable safety profile and represents a potential alternative for patients who have failed non-invasive weight loss therapies. - EndoZip™ is designed to reduce operator dependency and procedural complexity compared to traditional endoscopic gastroplasty, with CE mark approval anticipated soon and ongoing FDA discussions.
- A bicenter, prospective, longitudinal observational study utilized MR-guided radiotherapy (MRgRT) to treat adrenal gland metastasis, emphasizing precision and minimizing radiation exposure. - Secure multiparty computation (MPC) was employed to analyze patient data jointly between two sites while maintaining data privacy and adhering to strict data protection laws. - The MPC framework, including Sharemind MPC and Federated Secure Computing, ensured that data remained within each clinical site, with only aggregate results accessible to researchers. - This approach facilitated detailed studies on rare cancers like adrenal gland metastases, overcoming privacy obstacles and advancing personalized oncology through collaborative data analysis.
