Health Science Library

$11.4 Million NIH Grant to Study Nitric Oxide Treatment for Newborns with Congenital Diaphragmatic Hernia

- A $11.4 million NIH grant funds a multi-center clinical trial to investigate the efficacy of nitric oxide in treating newborns with congenital diaphragmatic hernia (CDH). - The NoNO Trial will randomize nitric oxide use at 19 institutions, comparing outcomes before and after de-implementation to assess its impact on oxygenation and ECMO needs. - The study aims to understand barriers to discontinuing nitric oxide use and address key management questions in CDH, a condition affecting 1 in 2,000-4,000 live births. - The University of Tennessee Health Science Center will serve as the clinical coordinating center, with the University of Texas Health Science Center directing data coordination.