HEARTFLOW, INC.

Heartflow FFRCT Analysis Cuts Unnecessary Invasive Heart Procedures by 44% in Government-Funded FUSION Trial

- The independent, government-funded FUSION trial showed adding Heartflow FFRCT Analysis to standard CCTA reduced unnecessary invasive coronary angiography by 44% at one year (p < 0.001). - Overall invasive catheterization rates fell significantly in the Heartflow pathway (43% vs. 61%; p < 0.001), while coronary revascularization rates remained identical across groups (20% vs. 20%). - No significant differences emerged in safety endpoints, including major adverse cardiac events, ICA complications, or stroke, confirming the approach safely avoids unnecessary procedures. - The late-breaking results, presented at ESC Congress 2026 and published in JACC, support routine integration of Heartflow FFRCT into clinical practice.