相关临床试验
114
4 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1949
已完成
63
55.3%
尚未招募
4
3.5%
招募中
41
36.0%
终止
1
0.9%
Unknown
3
2.6%
暂无批准数据
- Scientists at Kanazawa University in Japan have developed Mic-628, an oral compound that activates the Per1 clock gene to advance circadian rhythms and potentially treat jet lag. - In mouse studies, a single dose of Mic-628 reduced adaptation time to simulated jet lag from seven days to four days, nearly halving recovery time. - The compound works by targeting specific clock gene machinery rather than inducing sedation, offering a potentially more effective approach than current treatments like melatonin or light therapy. - Mic-628 demonstrated consistent effectiveness regardless of administration timing, which could simplify dosing schedules for travelers crossing multiple time zones.
- Zimmer Biomet received Japan PMDA approval for the iTaperloc Complete and iG7 Hip System, marking the world's first approved orthopedic implants with iodine technology designed to inhibit bacterial adhesion and prevent biofilm formation. - The innovative system addresses periprosthetic joint infection (PJI), which occurs in 1-2% of primary total joint arthroplasty procedures and carries mortality rates approaching those of breast cancer at 11%. - The iodine technology applies a controlled-release iodine layer through advanced anodization and electrophoresis during manufacturing, utilizing iodine's biocompatible properties without causing antibiotic resistance. - This approval strengthens Zimmer Biomet's infection management portfolio and represents a significant advancement in orthopedic implant design for improving patient safety in joint replacement surgeries.
