Keck School of Medicine of The University of Southern California

Metformin Shows Promise in Preventing Severe Morning Sickness in Early Studies

- Early research suggests metformin, a common diabetes medication, may reduce the risk of hyperemesis gravidarum by more than 70% when taken before pregnancy. - The protective effect appears linked to metformin's ability to raise GDF15 hormone levels, potentially training the body to tolerate hormonal changes during pregnancy. - Two observational studies provide preliminary evidence, but clinical trials are needed to confirm efficacy and establish optimal dosing protocols. - The findings could offer new hope for preventing a severe pregnancy complication that affects thousands annually and often influences family planning decisions.