Longboard Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company, which engages in the research and development of medicines for neurological diseases. The company was founded on January 3, 2020 and is headquartered in San Diego, CA.
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- The developmental and epileptic encephalopathies (DEE) market reached USD 2.2 billion across the 7MM in 2025, with the United States accounting for approximately 59% of the total market share. - The diagnosed prevalent population of DEE in the 7MM is projected to rise from approximately 288,000 in 2025 to 326,000 by 2036, reflecting improved genetic testing and diagnostic awareness. - A robust pipeline featuring antisense oligonucleotides, gene therapies, and precision medicines—including zorevunersen, bexicaserin, and relutrigine—is expected to reshape the treatment landscape for genetically defined DEE subtypes. - Praxis Precision Medicines' relutrigine received FDA Priority Review acceptance in March 2026 with a PDUFA target action date of September 27, 2026, for SCN2A and SCN8A DEEs.
- Bright Minds Biosciences completed a $175 million public offering to fund clinical trials for its lead epilepsy drug BMB-101, which targets childhood epilepsy through selective serotonin 5-HT2C receptor activation. - The company's BMB-101 compound is designed to avoid the cardiac and psychedelic side effects that plagued previous drugs like fenfluramine by selectively targeting the 2C receptor while avoiding 2A and 2B receptors. - Phase II trial results for BMB-101 in developmental epileptic encephalopathies and absence epilepsy are expected around the end of this year, with the company's stock having appreciated approximately 5,000% over the past 12 months. - Recent acquisitions in the epilepsy space, including Lundbeck's $2.6 billion purchase of Longboard Pharmaceuticals for a similar serotonin 2C mechanism drug, highlight strong industry interest in this therapeutic approach.
• A new report offers an overview of the clinical trial landscape for Dravet Syndrome, also known as Severe Myoclonic Epilepsy of Infancy, providing key data and analysis. • The review includes data on trial numbers, average enrollment, and top countries involved, segmented by region, phase, status, endpoints, and sponsor type. • Key companies like Jazz Pharmaceuticals, UCB, Takeda, and others are profiled, with details on their ongoing trials and prominent drugs in development for Dravet Syndrome. • The report identifies trends in clinical trial enrollment over the past five years and highlights recent news related to Dravet Syndrome research and development.
- Bexicaserin demonstrated a 59.3% median reduction in countable motor seizures over 12 months in patients with developmental and epileptic encephalopathies (DEEs). - The PACIFIC open-label extension study showed consistent seizure reduction in both patients who switched from placebo to bexicaserin and those who continued treatment. - Longboard Pharmaceuticals, now acquired by Lundbeck, is advancing bexicaserin into Phase 3 trials, including the DEEp SEA study for Dravet syndrome. - Bexicaserin's favorable safety profile and tolerability were maintained throughout the 12-month extension, supporting its potential as a treatment for DEEs.
- Longboard Pharmaceuticals has commenced the Phase III DEEp OCEAN study to evaluate bexicaserin for seizures associated with developmental and epileptic encephalopathies (DEEs). - The global, double-blind, placebo-controlled trial will monitor countable motor seizures in approximately 320 participants aged two years and above. - Bexicaserin, a 5-HT2C receptor superagonist, has received breakthrough status from the FDA for this indication, addressing a critical unmet need in DEE treatment. - Eligible participants can join a 52-week open-label extension after the 12-week maintenance period, further assessing the drug's long-term safety and efficacy.
- Longboard Pharmaceuticals has initiated the Phase 3 DEEp OCEAN study to evaluate bexicaserin for seizures associated with Developmental and Epileptic Encephalopathies (DEEs). - The DEEp OCEAN trial is a global, double-blind, placebo-controlled study involving approximately 320 participants aged two to 65 years. - Bexicaserin, a selective 5-HT2C receptor superagonist, has received Breakthrough Therapy designation from the FDA for DEEs. - The study aims to address a crucial unmet need in the DEE community by providing access to innovative medications and tailored clinical trials.
- Longboard Pharmaceuticals initiated a Phase 3 clinical trial, DEEp SEA, to evaluate bexicaserin in Dravet syndrome patients aged 2-65 years. - Bexicaserin received Orphan Drug and Rare Pediatric Disease designations from the FDA for treating Dravet syndrome, highlighting its potential impact. - The EMA's Paediatric Committee issued a positive opinion on the Paediatric Investigation Plan for bexicaserin in children as young as two years old. - Lundbeck A/S is set to acquire Longboard, marking a strategic move to further develop novel neurological disease treatments.
- Longboard Pharmaceuticals has started a Phase 3 clinical trial, DEEp SEA, to assess bexicaserin in Dravet syndrome patients aged 2-65 years. - Bexicaserin, a selective 5-HT2C receptor superagonist, continues to show sustained seizure reduction and a favorable safety profile in DEEs. - The FDA granted Orphan Drug and Rare Pediatric Disease designations to bexicaserin for treating Dravet syndrome, highlighting its potential impact. - H. Lundbeck A/S is set to acquire Longboard, a strategic move following positive developments in bexicaserin's clinical program.
- Over 90 epilepsy treatment therapies are under development by more than 75 companies globally, targeting various mechanisms of action and routes of administration. - Longboard Pharmaceuticals reported positive Phase Ib/IIa results for LP352 (bexicaserin) in developmental and epileptic encephalopathies (DEEs), showing a significant reduction in seizure frequency. - Amzell has initiated a study comparing AMZ002 with Vigabatrin for treating infantile spasms, a rare and severe form of epilepsy, to assess efficacy and safety. - Emerging therapies like RLS103, CT-010, Darigabat, and XEN496 are in different clinical trial phases, indicating potential advancements in epilepsy management.
- Lundbeck will acquire Longboard Pharmaceuticals for $2.6 billion, gaining bexicaserin, a promising drug for developmental and epileptic encephalopathies (DEEs). - Bexicaserin, a 5-HT2C receptor superagonist, has shown encouraging results in clinical trials for reducing seizure frequency in Dravet syndrome and other DEEs. - The acquisition aligns with Lundbeck's strategy to expand its neuro-rare disease portfolio, with bexicaserin potentially launching in 2028 and reaching peak sales of $1.5-2 billion. - The deal is expected to close in the fourth quarter of 2024, pending regulatory approvals and tender of Longboard's outstanding shares.
