MARQUETTE UNIVERSITY

Lemon Frost Gecko Emerges as Promising Natural Model for Human Cancer Research

- A University of Nottingham-led study published in BMC Biology identifies the lemon frost leopard gecko as a novel animal model for studying cancer, with tumors appearing naturally in approximately 80% of individuals. - Whole-genome sequencing revealed recurring genetic changes in gecko tumors that affect the same genes and biological pathways implicated in human cancers. - Unlike laboratory mice that require tumor induction, lemon frost geckos develop aggressive, metastatic tumors at a relatively young age, offering a rare window into natural cancer progression. - Researchers emphasize that studying species across the tree of life, including cancer-susceptible and cancer-resistant animals, could inspire new strategies for cancer prevention, detection, and treatment in humans.