NATIONAL CENTRE FOR INFECTIOUS DISEASES

Singapore Launches First COVID-19 Human Challenge Trial with Five Volunteers

- Singapore's National Centre for Infectious Diseases has conducted the country's first COVID-19 human challenge study, deliberately exposing five vaccinated volunteers to the virus under controlled conditions. - The Sing-CoV trial aims to recruit 20 healthy participants aged 21-30 by October 2024, with researchers collecting comprehensive biological samples to gain precise insights into infection dynamics despite vaccination. - This pioneering study establishes a framework for future challenge trials, including the upcoming global MUSICC study in 2025, strengthening Singapore's preparedness for future pandemics including potential "Disease X" threats.