相关临床试验
2447
65 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
N/A
Unknown
21
0.9%
已完成
1921
78.5%
Enrolling By Invitation
13
0.5%
尚未招募
14
0.6%
No Longer Available
2
0.1%
终止
181
7.4%
招募中
157
6.4%
暂停
5
0.2%
撤回
95
3.9%
进行中（未招募）
38
1.6%
暂无批准数据
- A multi-institutional team discovered MWAC-3634, a small molecule that blocks Ebola virus entry by stabilizing the viral entry protein rather than destabilizing it. - Screened from roughly 4.73 billion molecules using DNA-encoded chemistry, the compound inhibited authentic Ebola virus with an IC50 of 0.65 nM. - In a lethal mouse model, 85.7% of orally treated mice survived versus 28.6% of controls, with 100% survival among injected mice. - MWAC-3634 showed 69% oral bioavailability, but researchers caution it remains experimental and has not been tested or approved for human use.
- IDSA and HIVMA raised alarm over an Aug. 28 NIH notice proposing a major overhaul of NIAID's clinical research program with few details and a brief comment period. - The restructuring follows months of delays in NIH renewal notices for NIAID clinical trial networks and Centers for AIDS Research, with HIV network renewals still pending. - The societies warn that destabilizing NIAID's HIV research infrastructure will harm study participants and compromise the U.S. infectious disease response amid worsening workforce shortages. - IDSA and HIVMA separately applauded Congress for a bipartisan continuing resolution blocking a proposed federal grant rule that would replace peer review with political alignment.
- Dolly Parton made a $1 million donation to Vanderbilt University Medical Center in March 2020 to support research into COVID-19 treatments, creating the Dolly Parton COVID-19 Research Fund. - The fund supported early-stage research that contributed to the COVID-19 vaccine developed by Moderna and the National Institute of Allergy and Infectious Diseases. - More than 250 million people globally received the Moderna COVID-19 vaccine, and COVID vaccinations overall are estimated to have saved at least 14 million lives in the first year of rollout. - Parton, who died this week at age 80 after a brief battle with cancer, also gave another $1 million in 2022 for pediatric infectious disease research.
- A new five-year, $3.22 million R01 grant from the National Institute of Allergy and Infectious Diseases will fund research into how Aspergillus fumigatus obtains nutrients inside the human lung. - The project, led by Jarrod Fortwendel, PhD, at the University of Tennessee Health Sciences College of Pharmacy, focuses on the poorly understood window between spore dormancy and invasive infection. - The work centers on the CotA protein, whose two isoforms appear to play distinct roles in sensing carbon sources and fueling aggressive, tissue-invading growth. - The research could point toward an entirely new class of antifungal targets aimed at cutting off the pathogen's food supply rather than killing it outright.
- Newly released January 2021 text messages show Dr. Anthony Fauci privately raised concerns that fever and cytokine storm after the second mRNA vaccine dose could theoretically be associated with first-trimester miscarriage. - The exchange involved Fauci, then-CDC Director Dr. Rochelle Walensky, and Dr. Vivek Murthy, who acknowledged the concern as "a really good point" warranting attention. - Fauci also noted that over 10,000 pregnant women had already been vaccinated with "no issues" reported and that FDA, ACIP, and ACOG guidance allowed pregnant women to choose vaccination. - The texts were released by Sens. Ron Johnson and Rand Paul as part of an ongoing oversight investigation involving more than 34,000 text messages from Fauci's government-issued phone.
- Dr. Anthony Fauci invoked the Fifth Amendment more than 100 times during a Senate Homeland Security Committee hearing on his handling of the COVID-19 pandemic. - Sen. Rand Paul announced the committee will vote next week on holding Fauci in contempt of Congress for refusing to answer questions after being subpoenaed. - Paul released over 1,000 pages of Fauci's personal diary, alleging contradictions between his private writings and public statements on lockdowns and pandemic origins. - More than 150 infectious-disease experts signed a public letter defending Fauci, calling the hearing a politically motivated "witch-hunt."
- New HIV patient enrollment fell 59% and viral load testing dropped 33% in Kenya, Uganda, and Tanzania during the first five weeks after January 2025 US funding withdrawal. - The UCSF-led analysis used patient-level data from nearly 103,000 people across 189 clinics, marking the first real-world measurement of the cuts' immediate impact. - Existing patients continued receiving treatment, but the funding pause created a bottleneck that prevented new patients from entering HIV care. - Young people and men, already less likely to access HIV services, experienced the steepest declines in enrollment.
- The NIH NIAID has awarded a five-year, $2.4 million R01 grant to Dr. Jiahui Ding at Wayne State University to study how maternal viral infections during pregnancy shape lifelong immune health in offspring. - The research focuses on the placenta as a key mediator, examining how placental inflammasome activation and IL-1β signaling reprogram fetal hematopoietic stem cells in a sex-dimorphic manner. - Preliminary findings indicate maternal viral infection impairs neutrophil function and increases inflammatory sensitivity predominantly in male offspring, suggesting sex-specific placental inflammatory pathways. - The project employs cutting-edge approaches including single-cell transcriptomics, epigenetic profiling, and an innovative human placenta–fetal interface organ-on-chip model.
- Revagenix has dosed the first participant in its Phase 1 clinical trial of Rev-56, an inhaled, first-in-class anti-pseudomonal therapy for non-cystic fibrosis bronchiectasis (NCFB). - Rev-56 targets chronic Pseudomonas aeruginosa, a key driver of exacerbations, hospitalizations, disease progression, and mortality in NCFB, for which no FDA-approved therapies currently exist. - Part A of the study will evaluate safety, tolerability, and pharmacokinetics in healthy volunteers, with topline data expected by year-end 2026. - NCFB affects an estimated 350,000 to 500,000 adults in the United States, and chronic P. aeruginosa infection is associated with the most severe disease trajectory.
- Florida Atlantic University, Brown University, and Florida International University received a five-year, $3.8 million NIH grant to develop new antimalarial drugs targeting the PfGARP protein. - The project builds on the discovery that antibodies against PfGARP trigger apoptosis in Plasmodium falciparum parasites within 12 to 24 hours, independent of other immune cells. - Researchers will use high-throughput screening to identify small molecules that mimic parasite-killing antibodies, creating a novel mechanism-based strategy to combat drug-resistant malaria. - Malaria caused approximately 263 million cases and nearly 600,000 deaths globally in 2023, with over 90% of fatalities occurring in sub-Saharan Africa and children under five disproportionately affected.
