相关临床试验
32
1 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1985
进行中（未招募）
1
3.1%
已完成
24
75.0%
招募中
4
12.5%
终止
1
3.1%
撤回
2
6.3%
暂无批准数据
- The OHSU Board of Directors passed a resolution to significantly reduce primate experiments and transition the Oregon National Primate Research Center toward nonanimal, human-based research. - The resolution anticipates eventual removal of the center's federal designation as a National Primate Research Center, reflecting a broader federal shift away from animal testing. - More than 550 physicians separately called on HHS Secretary RFK Jr. to phase out primate experimentation across all seven National Primate Research Centers. - Modern human-based methods including organoids, microphysiological systems, and computational modeling are cited as more predictive of human outcomes than animal experiments.
- The Summer Immersion on Innovative Approaches in Science trained 150 global attendees in human-based new approach methodologies (NAMs) at Johns Hopkins Bloomberg School of Public Health. - The tuition-free, four-day program featured hands-on workshops in organ-on-a-chip systems, bioprinting, computational toxicology, and other human-relevant technologies. - All post-event survey respondents indicated they are likely to pursue careers using nonanimal methods, with one attendee stating they now seek to "exclusively incorporate NAMs" into future research. - The program was named a winner of the NCATS Translational Science Education and Training challenge, recognizing it as an exemplary model of translational science education.
- Swapping animal protein for plant protein led to significant weight loss in postmenopausal women without reducing total protein intake, according to a randomized clinical trial published in Menopause. - A shift of approximately 16 grams less animal protein and 13 grams more plant protein per day was associated with a 1-kilogram (2.2-pound) weight loss, independent of calorie intake. - Reductions in methionine intake, an amino acid more abundant in animal products, were significantly linked to decreases in body mass index, suggesting a metabolic mechanism. - The dietary approach also reduced moderate-to-severe hot flashes by 88% in the original trial, offering dual benefits for weight management and menopausal symptoms.
- A new Physicians Committee for Responsible Medicine/Morning Consult survey of 2,200 U.S. adults finds one in five unaware that diet directly affects blood cholesterol levels. - Among those aware, 52% learned from healthcare providers, while 36% and 34% cited friends/family and social media respectively as information sources. - Over one-third of respondents incorrectly believe chicken reduces cholesterol risk; 26% and 18% held the same misconception about lean red meat and eggs. - A 2019 study confirmed both white and red meat raise LDL cholesterol similarly compared to plant-based proteins, and over half of respondents expressed willingness to try a plant-based diet.
- The NIH has established the Office of Research Innovation, Validation, and Application (ORIVA) to coordinate agency-wide adoption of nonanimal, human-based research approaches like organoids and tissue chips. - ORIVA will serve as an interagency hub, facilitating cross-agency validation efforts with the FDA and EPA to update testing guidance and resource allocation. - Since April 2025, the NIH has awarded over $150 million for human-based research technology development and has ceased releasing funding opportunities exclusively focused on animal-based projects. - The Physicians Committee for Responsible Medicine has provided strategic recommendations for the NIH FY 2026-2031 plan, including increased training, infrastructure investment, and stronger animal-use justification policies.
