相关临床试验
57
7 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1946
进行中（未招募）
3
5.3%
已完成
33
57.9%
尚未招募
4
7.0%
招募中
14
24.6%
Unknown
3
5.3%
暂无批准数据
- Researchers at Pusan National University developed injectable, biodegradable hyaluronic acid microgels that act as localized radiation reservoirs for keloid treatment. - The freeze-dried microgels achieve over 90% iodine-131 labeling efficiency in under 10 minutes and remain localized within keloid tissue for up to 14 days. - In preclinical models, iodine-131-labeled microgels induced more than 80% keloid fibroblast death within 48 hours and reduced keloid size by about 70% after two weeks. - The platform offers a promising "off-the-shelf" microbrachytherapy approach that overcomes the targeting limitations of conventional external-beam radiation for small, irregular lesions.
- Researchers at Pusan National University identified the GDF15–IDO1–kynurenine–AhR signaling axis as a key driver of natural killer (NK) cell exhaustion in immunologically "cold" tumors such as ovarian, breast, and prostate cancers. - Persistent AhR activation under chronic environmental and metabolic stress reprograms NK cells from an active tumor-killing state into a dysfunctional, exhausted state that enables immune escape. - Blocking AhR signaling restored NK-cell function, positioning the GDF15–AhR axis as a promising therapeutic target for converting cold tumors into immunotherapy-responsive tumors. - Circulating GDF15 levels combined with NK-cell AhR activity may serve as biomarkers to predict immunotherapy response and guide personalized treatment decisions.
