The Royal Orthopaedic Hospital NHS Foundation Trust

First Clinical Study Demonstrates Feasibility of Fluorescence Imaging in Orthopaedic Surgery

- A prospective 10-patient pilot study published in BMJ Open provides the first clinical evidence supporting MolecuLight fluorescence imaging during revision knee arthroplasty for periprosthetic joint infection. - Surgeons used the MolecuLightDX device after standard debridement to detect residual bacterial burden; areas of fluorescence were biopsied and confirmed to harbor the same bacterial species causing the infection. - Senior author Professor Jonathon Stevenson stated the findings suggest MolecuLight may assist surgeons in improving radical debridement, a key step in minimizing recurrent infection morbidity. - Researchers and MolecuLight leadership emphasize that larger studies are needed to confirm findings and explore the potential for reducing additional resection surgeries and infection complications.