相关临床试验
20
1 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1881
已完成
16
80.0%
尚未招募
1
5.0%
招募中
3
15.0%
暂无批准数据
- Japanese researchers have isolated 10 natural compounds called onnamides from Okinawan marine sponges, with two showing exceptional activity against Leishmania major parasites. - Onnamide A and 6,7-dihydro-onnamide A demonstrated superior potency and safety compared to current leishmaniasis treatments, while operating through distinct mechanisms that could overcome drug resistance. - The compounds showed strong selectivity for parasites over human cells and may enable shorter treatment durations at lower concentrations. - Research is advancing under Japan's AMED Drug Discovery Booster program, with efforts underway to develop sustainable production methods using symbiotic bacteria.
- Japanese researchers have developed a simplified DNA hydrogel using only two oligodeoxynucleotides, requiring just 68 nucleotides total - significantly less than conventional methods that use twelve different 40-base strands. - The optimized Takumi-shaped DNA hydrogel demonstrated sustained retention for over 168 hours post-administration in mice, showing superior performance compared to existing hexapodna-based systems. - In vivo experiments with doxorubicin-loaded hydrogels showed pronounced anti-tumor effects through sustained drug release, highlighting potential applications in targeted cancer therapy.
