相关临床试验
973
122 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1960
进行中（未招募）
65
6.7%
已完成
559
57.5%
Enrolling By Invitation
21
2.2%
No Longer Available
1
0.1%
尚未招募
36
3.7%
招募中
143
14.7%
暂停
2
0.2%
终止
56
5.8%
Unknown
35
3.6%
撤回
55
5.7%
暂无批准数据
- A first-in-human phase 1 trial in Cell reports that a single infusion of glycocalyx-edited autologous mesenchymal stromal cells was well tolerated in 10 women with advanced osteoporosis. - Fracture incidence fell from 8 events per year in the two years before infusion to 0.5 events per year in the two years after, a 94 percent reduction. - Bone biopsies at day 120 showed increased bone tissue area in 7 of 10 patients, alongside rises in bone formation biomarkers and improved trabecular bone density on imaging. - Researchers caution the trial was small, uncontrolled, and mostly enrolled patients on conventional osteoporosis drugs, so larger and more diverse studies are needed.
- Researchers at UC San Diego demonstrated that E. coli RNA polymerase can accurately read and transcribe an expanded, eight-letter genetic alphabet rather than only DNA's natural four-letter code. - High-resolution cryo-electron microscopy revealed the enzyme recognizes synthetic DNA letters through the same biochemical and structural signals as natural base pairs. - A related PNAS study showed RNA polymerase can also recognize synthetic base pairs held together without hydrogen bonds. - The findings provide a molecular foundation for future diagnostics, therapeutics, and engineered biological systems using expanded genetic codes.
- A UC San Diego and UC Berkeley study published in Science Advances links certain California landscapes to differing Valley fever rates, a fungal infection caused by inhaling Coccidioides spores. - Researchers analyzed 65,657 confirmed Valley fever cases from April 2008 to March 2021, finding shrubland, barren land, grassland, and some crop types associated with higher disease incidence. - Newly fallowed farmland was linked to higher Valley fever rates, with the relationship varying by the land's previous cultivation history. - Findings support dust-control measures and protective measures such as N95 masks as California's landscapes and land use patterns change.
- Researchers at UC San Diego used high-throughput DNA sequencing and machine learning to decode the DNA "initiator," a key element controlling gene activation. - The AI model provided the first strong predictions of initiator presence or absence, revealing that roughly 60% of human genes contain this sequence. - The findings could help predict how DNA mutations affect gene activity and support the design of synthetic promoters with customized functions. - The work represents a step toward building AI models of the full human gene expression code spanning six billion DNA bases.
- XPRIZE announced 20 Finalist Teams advancing in the $101 million Healthspan competition, with 10 teams each receiving $1 million Milestone 2 awards to accelerate clinical development. - The competition aims to restore muscle, cognition, and immune function by a minimum of 10 years in adults aged 50–90, with treatments lasting one year or less. - UC San Diego's Stein Institute will serve as the Central Laboratory and Biorepository, providing standardized multi-omics analysis and biomarker profiling for all finalist teams. - Coordinated clinical trials will run from 2026 to 2029, with the grand prize of up to $81 million to be awarded in 2030.
- UC San Diego researchers identified the MITF/TFE protein family as a master genetic switch that drives neurodegeneration in both Sanfilippo syndrome type A and Alzheimer's disease. - The study, published in Immunity, shows that lysosomal waste buildup in microglia triggers a protective response that eventually becomes maladaptive, fueling inflammation and neuronal death. - Findings suggest a new drug development strategy targeting the lysosomal program inside microglia rather than cell-surface receptors, with early intervention potentially most effective. - The research provides a clear framework for studying common neurodegenerative diseases using MPS IIIA, a rare disorder with a single-gene cause.
- UC San Diego's FY26 sponsored research awards totaled nearly $1.8 billion, with federal sources comprising 62% of funding, a 19% increase over the prior year. - The number of new awards declined to 1,746 from 1,925 in FY25, indicating researchers are winning larger but fewer, more competitive grants. - A landmark ARPA-H award of up to $25.8 million supports development of a 3D bioprinted liver from patient-derived cells to address organ failure. - Philanthropic giving reached $470 million, including $458.5 million in private support, bolstering research continuity amid federal funding uncertainty.
- UC San Diego engineers developed the first fully integrated smart ring that continuously monitors up to four chemical biomarkers from finger sweat without requiring exercise. - The ring tracks glucose, ketones, vitamin C, uric acid, lactate, and alcohol, with glucose readings closely matching commercial CGMs and ketone readings matching blood meters. - Sweat is collected passively via an osmotic hydrogel technique, and the ring operates for up to 12 hours on a flexible rechargeable battery. - Simultaneous glucose and ketone monitoring could significantly benefit insulin dosing optimization for type 1 diabetes management.
- Two children with SCN2A-related developmental epileptic encephalopathy received allele-selective antisense oligonucleotides tailored to their individual mutations in n-of-1 trials published in Nature Medicine. - The 14-year-old patient experienced a 90% reduction in seizure frequency and walked independently for the first time at age 15, while the 9-year-old saw a 26% drop. - Both patients showed developmental gains in language, motor skills, and adaptive behaviors, with no serious adverse events reported over the two-year treatment period. - The investigational approach provides a model for rapidly translating personalized genetics into treatments for other monogenic neurological and non-neurological diseases.
- UC San Diego bioengineers published the first genome-scale map of gene function in human induced pluripotent stem cells in Nature Biotechnology. - The team used CRISPR interference to switch off 11,692 expressed genes one by one and measured transcriptome effects across more than 2.5 million single cells. - The open-access atlas revealed previously hidden metabolic and self-renewal genes and identified DBR1 as the main regulator of adenosine-to-inosine RNA editing. - Researchers position the map as a hypothesis engine to guide differentiation targets and power future AI tools for genotype-phenotype prediction.
