UNIVERSITY OF FUKUI

Japanese Researchers Begin Human Trials for Revolutionary Tooth Regeneration Drug

- Japanese scientists have initiated clinical trials for a groundbreaking drug that could enable humans to regrow missing or damaged teeth by targeting the USAG-1 protein. - The therapy works by suppressing USAG-1, a protein that limits tooth growth, with successful preclinical results demonstrated in mice and ferrets. - Initial human trials will test 30 men aged 30-64 missing at least one tooth, with plans to expand to children with congenital tooth absence if proven safe. - Researchers aim to make the treatment available to the general public by 2030, potentially revolutionizing dental care for millions worldwide.