相关临床试验
128
22 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1862
进行中（未招募）
9
7.0%
已完成
60
46.9%
Enrolling By Invitation
2
1.6%
尚未招募
11
8.6%
招募中
13
10.2%
终止
8
6.3%
Unknown
20
15.6%
撤回
5
3.9%
暂无批准数据
- Researchers reviewed 77 meta-analyses spanning 116 different bipolar disorder treatments to identify the most effective interventions across age groups and mood phases. - The team created EBI-BD, an open-access web platform presenting each treatment's impact, side effects, and strength of evidence to support shared decision-making. - For bipolar depression, effective adult treatments include cariprazine, fluoxetine, and lurasidone, while lurasidone and olanzapine with fluoxetine were effective in children and teenagers. - The review's results have already been used to update CANMAT and International Society for Bipolar Disorders (ISBD) treatment guidelines.
- University of Southampton researchers identified a distinct air pollution signature from cruise ships burning fuel in ports, with ultrafine particulate matter enriched in vanadium, nickel, and cobalt. - Lab tests on human lung cells showed that exposure to these particles increased inflammatory gene expression and suppressed antiviral responses, facilitating replication of rhinovirus and SARS-CoV-2. - Vanadium, the most enriched trace element in the emissions, was found to directly diminish the ability of cells to prevent viral replication, with potential implications for infection severity and spread. - The study calls for adoption of shoreside power, alternative fuels, and enhanced emissions reduction technology, alongside increased monitoring of unregulated ultrafine particulate matter near ports worldwide.
- A new initiative called Island and Institutes partners Business Beats Cancer Guernsey with the universities of Southampton and Sussex to bring clinical research access to the island. - Blood cancer patients in Guernsey can now consent to have excess blood and tissue samples transported to the UK for use in ongoing clinical trials without needing to travel. - Lead oncologist Peter Gomes stated the program would be "very positive" in allowing patients to contribute to research that improves treatments for all. - Results will be shared with the local oncology team and could lead to more targeted treatments becoming available on the island.
- Patient and public involvement (PPI) is now a mandatory requirement for most UK medical research funders, including detailed PPI plans in grant applications. - Basic, preclinical, and laboratory-based research presents unique PPI challenges due to its distance from patient lived experience, yet offers significant benefits for research relevance. - Experts argue that evaluating the PPI process is as important as measuring its impact, emphasizing continuous improvement and meaningful engagement over simple justification. - Researchers should use frameworks like the UK Standards for Public Involvement and provide feedback to public contributors to ensure they feel valued and motivated.
- C-Further, an international pediatric oncology consortium, unveiled its first two therapeutic programs targeting childhood cancers including Ewing sarcoma, bone sarcoma, medulloblastoma, and acute myeloid leukemia with $40 million in initial funding. - CF-012 represents a potential first-in-class ETV6 inhibitor for Ewing sarcoma developed in collaboration with UVA Comprehensive Cancer Center, Dana-Farber Cancer Institute, and Mass General Brigham. - CF-033 is an allogeneic PRAME-targeted iNKT cell therapy developed with MiNK Therapeutics that requires no HLA matching or toxic lymphodepletion, designed for multiple pediatric cancers. - MiNK Therapeutics will receive approximately $1.1 million in non-dilutive funding plus meaningful double-digit commercial revenue participation for the PRAME-targeted program.
- The phase III SCOT trial demonstrated noninferiority of 3-month versus 6-month adjuvant oxaliplatin plus fluoropyrimidine chemotherapy for overall survival in colorectal cancer patients. - Among 6,088 patients, 5-year overall survival was identical at 82.4% for both treatment durations, with noninferiority confirmed for CAPOX but not FOLFOX regimens. - The shorter treatment duration significantly reduced toxicities including sensory neuropathy, diarrhea, and neutropenia while maintaining equivalent survival outcomes. - Results support recommending 3-month adjuvant chemotherapy for most patients with high-risk stage II and stage III colorectal cancer.
- A multicenter trial with 150 children and adolescents found that trigeminal nerve stimulation (TNS), cleared by the FDA in 2019 for ADHD treatment, showed no significant improvement in core symptoms compared to sham treatment. - The study revealed a substantial placebo effect, with both real and sham groups showing 26-29% symptom improvement, highlighting the importance of rigorous control conditions in neurotechnology trials. - While TNS demonstrated excellent safety with no serious adverse events and high acceptability among participants, the findings challenge the original evidence that supported FDA clearance and suggest authorities should revisit the approval.
- Researchers at Oregon Health & Science University have achieved the first successful transformation of human skin cells into functional eggs capable of fertilization and early embryonic development. - The team developed a novel technique called "mitomeiosis" that combines somatic cell nuclear transfer with artificial chromosome reduction to create eggs with the correct 23-chromosome count. - While only 9% of the 82 created eggs developed to the blastocyst stage and most showed chromosomal abnormalities, the proof-of-concept study demonstrates the feasibility of creating gametes from ordinary body cells. - Clinical applications remain at least 10-15 years away due to technical challenges in achieving proper chromosome segregation and the need for extensive safety testing.
- Scientists from the University of Sheffield and AstraZeneca developed MapDiff, an AI framework that outperforms existing methods for inverse protein folding, a critical process in designing therapeutic proteins. - A separate research team from Chongqing University and Zhejiang University created an AI tool that generated 7,245 new proteins designed to bind to targets like viruses and cancer markers. - These AI advances could significantly accelerate drug development timelines by reducing months of laboratory work to weeks while improving protein stability and functionality. - The breakthrough technologies complement existing tools like AlphaFold and could enable faster development of vaccines, gene therapies, and diagnostic tools.
- New research from Penn State reveals that vitamin D deficiency in early pregnancy is associated with a fourfold increase in preterm birth rates and smaller infant size at delivery. - A complementary study by the University of Southampton demonstrates that maternal vitamin D supplementation during pregnancy leads to stronger, denser bones in children that persist until at least age 7. - Scientists emphasize that vitamin D monitoring should be prioritized alongside other essential nutrients during preconception and early pregnancy to promote optimal fetal development and long-term health outcomes.
