相关临床试验
7
3 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1890
进行中（未招募）
2
28.6%
已完成
1
14.3%
Enrolling By Invitation
1
14.3%
招募中
3
42.9%
暂无批准数据
- Researchers developed a single Vision Transformer AI model that predicts TP53 mutation status, RNA expression, tumor type, and survival outcomes from routine H&E whole slide images. - The model achieved an AUROC of 0.766 for TP53 mutation detection across 32 solid tumor types in an independent validation set of 1,729 slides. - Trained on over 11,000 primary tumor cases from the Pan-Cancer Atlas, the model uses weakly supervised learning to avoid costly pixel-level annotations. - Investigators emphasize the tool is complementary to molecular testing, serving as a screening, prioritization, and decision-support aid rather than a replacement.
- A six-month clinical trial found that metformin, a common diabetes medication, significantly reduced knee osteoarthritis pain in overweight patients by 31.3 points compared to 18.9 points in the placebo group. - Researchers from Monash University and collaborating institutions suggest metformin could be used "off-label" as a safe, low-cost treatment option that may delay the need for knee replacement surgery. - Beyond pain reduction, participants taking metformin also reported significantly improved joint stiffness and function, with only mild-to-moderate gastrointestinal side effects reported in 30% of treatment group patients.
