Early detection of head and neck cancer relapse by expression profiling of blood platelets and/or ctDNA analysis in plasma and oral rinses

Recruiting

• Conditions: Hoofd-hals neoplasmata maligne; head and neck cancer; Squamous Cell Carcinoma of Head and Neck

• Registration Number: NL-OMON49182
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 94

Inclusion Criteria

Patients must have an HNSCC, sufficient knowledge of the Dutch language to
understand the meaning of the study as described in the patient information,
signed informed consent for the study, be 18 years of age or older

Exclusion Criteria

Patiets who are scheduled for palliative treatment

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Endpoints of the study are the accuracy of early detection of relapse by ctDNA<br /><br>and/or TEP analyses in head and neck cancer patients during follow-up. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The median time frame of a positive test and the diagnosis of relapse<br /><br>- The presence of ctDNA in persurgery wound rinses as risk factor for relapse<br /><br>- Association of mutations in ctDNA with primary tumor and relapse<br /><br>- The role of intratumor genetic heterogeneity between primary tumor and<br /><br>relapse in relation to ctDNA detection</p><br>