Comparison of body composition analysis by densitometry with methods of microcirculation analysis and inflammatory cytokines
- Conditions
- ObesityVisceral adiposityEndothelial dysfunctionLow grade inflammationBody compositionDXAObesityVisceral adiposityEndothelial dysfunctionLow grade inflammationMicrocirculation
- Registration Number
- TCTR20221018004
- Lead Sponsor
- IVERSIDADE DO ESTADO DO RIO DE JANEIRO - UERJ
- Brief Summary
Adiposity assessed by DXA, notably, visceral adiposity tissue and anthropometric measures of adiposity have been demonstrated inverse correlations with blood flow from the forearm during reactive hyperemia, indicating a decline in endothelial function with advancing from adiposity. There was no impairment of endothelium-independent vasodilation in the groups evaluated. A decline in endothelial function was identified in individuals with greater levels of hs CRP.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 101
Inclusion criteria were age range between 18 and 50 years old, apparently healthy, without evidence of inflammatory state, blood pressure levels < 180 x 110 mm Hg and hyperglycemia or glycated hemoglobin, not compatible with DM diagnosis
The main exclusion criteria were: diabetes mellitus; hypertension with blood pressure (BP) levels greater or equal 180x110 mm Hg; history of acute myocardial infarction; stroke; peripheral arterial obstructive disease or deep vein thrombosis. Individuals with previous history of bariatric surgery, smoking or currently using statins, phosphodiesterase 5 inhibitors and anti-inflammatory drugs were excluded
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method visceral adiposity single assessment dual-energy X-ray absorptiometry
- Secondary Outcome Measures
Name Time Method endothelial function single assessment venous occlusion plethysmography