In vivo imaging of amyloid-beta deposition in Alzheimer's disease
Completed
- Conditions
- hersenaandoeningcognitive dysfunctiondementia
- Registration Number
- NL-OMON33273
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
- Diagnosed with probable Alzheimer's disease
- Diagnosed as memory complainer
- Capable of giving informed consent
Exclusion Criteria
- Contra-indication to MRI scanning:
• Claustrophobia
• Pacemakers and defibrillators
• Nerve stimulators
• Intracranial clips
• Intraorbital or intraocular metallic fragments
• Cochlear implants
• Ferromagnetic implants
• Hydrocephaluspump
• Intra-utrine device
• An iron wire behind the teeth
• Permanent make-up
• Tattoos above the shoulders
- MMSE < 19 points
- Severe physical restrictions (completely wheelchair dependent)
- Fear or problems during the 3T MRI scan
- Age above 90
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter will be a qualitative measure of the presence of<br /><br>distinct hypointense cortical foci and an inhomogeneous aspect of the cortex.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameter will be a quantitative measure of susceptibility<br /><br>related changes in the cortex.</p><br>