Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)
- Conditions
- Alcohol Use Disorder
- Interventions
- Drug: Intravenous Ethanol
- First Posted Date
- 2025-06-19
- Last Posted Date
- 2025-07-03
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 30
- Registration Number
- NCT07027839
- Locations
- πΊπΈ
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
- Conditions
- Long COVIDPost Acute Sequelae of COVID-19
- Interventions
- Drug: 11C-PS13
- First Posted Date
- 2025-04-10
- Last Posted Date
- 2025-06-24
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 60
- Registration Number
- NCT06920628
- Locations
- πΊπΈ
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder
- First Posted Date
- 2025-03-25
- Last Posted Date
- 2025-03-26
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 30
- Registration Number
- NCT06795581
- Locations
- πΊπΈ
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
- Conditions
- Healthy
- Interventions
- Drug: 11C-JMJ-129
- First Posted Date
- 2025-03-13
- Last Posted Date
- 2025-05-31
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 40
- Registration Number
- NCT06874205
- Locations
- πΊπΈ
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety
- Conditions
- Psychiatric DisordersAnxiety Disorders
- Interventions
- Behavioral: Gaze-Contingent Music Reward Therapy
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2025-07-02
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 150
- Registration Number
- NCT06595953
- Locations
- πΊπΈ
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
- Conditions
- SuicideDepressive Disorder, Treatment-ResistantMolecular Mechanisms of Pharmacological ActionNeurotransmitter AgentsExcitatory Amino Acid AgentsKetaminePhysiological Effects of DrugsDepressive Disorder, MajorMental DisordersMood Disorders
- Interventions
- Drug: (2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg)Drug: Placebo
- First Posted Date
- 2024-07-22
- Last Posted Date
- 2025-06-22
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 50
- Registration Number
- NCT06511908
- Locations
- πΊπΈ
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers
- Conditions
- Irritability
- Interventions
- Other: Frustration task
- First Posted Date
- 2024-07-03
- Last Posted Date
- 2025-06-13
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 80
- Registration Number
- NCT06484088
- Locations
- πΊπΈ
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
πΊπΈTexas A&M University, College Station, Texas, United States
Natural History of Depression, Bipolar Disorder and Suicide Risk
- Conditions
- Excitatory Amino Acid AgentsMolecular Mechanisms of Pharmacological ActionAnesthetics, DissociativeBehavioral SymptomsSuicideSelf-Injurious BehaviorAnestheticsDepression, UnipolarDepressive SymptomsDepression, Bipolar
- First Posted Date
- 2024-06-17
- Last Posted Date
- 2025-07-02
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 500
- Registration Number
- NCT06462196
- Locations
- πΊπΈ
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Efficacy of Mirtazapine in Major Depressive Disorder With Insomnia
- Conditions
- Major Depressive Disorder With Insomnia
- Interventions
- First Posted Date
- 2023-08-07
- Last Posted Date
- 2024-04-02
- Lead Sponsor
- National Institute of Mental Health, Dhaka
- Target Recruit Count
- 135
- Registration Number
- NCT05978219
- Locations
- π§π©
National Institute of Mental Health, Dhaka, Bangladesh
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
- Conditions
- Depression
- Interventions
- First Posted Date
- 2023-01-30
- Last Posted Date
- 2025-03-27
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 108
- Registration Number
- NCT05703685
- Locations
- πΊπΈ
National Institutes of Health Clinical Center, Bethesda, Maryland, United States