MR-Fingerprinting for the Prediction of the Response of Vestibular Schwannomas to Gamma Knife Radiosurgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Tumor growth
研究概览
简要总结
MR Fingerprinting (MRF) will be performed in patients who will be treated with Gamma Knife radio surgery for a vestibular schwannoma before the intervention. Fifty patients will be included with a vestibular schwannoma of minimum 1cm in size. During follow-up, response of the tumor to radiosurgery will be evaluated for each patient with MRI. The aim of the study is to find patterns of vestibular schwannomas in MRF data which correlate with the type of response to radio surgery, i.e. tumor control after radiosurgery, further tumor growth despite radiosurgery, cystic transformation after radiosurgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Planned Gamma Knife radiosurgery for vestibular schwannoma of minimum 1cm in size -
排除标准
- •Vestibular Schwannoma of less than 1cm in size. Other a priori treatment than Gamma Knife radiosurgery
结局指标
主要结局
Tumor growth
时间窗: 3 years
Number of patients with growth of the tumor on follow-up MRI after radiosurgery
Tumor control
时间窗: 3 years
Number of patients without further growth of the tumor on follow-up MRI after radiosurgery
Cystic transformation
时间窗: 3 years
Number of patients with cystic transformation of the tumor on follow-up MRI after radiosurgery
次要结局
未报告次要终点
研究者
Josa M Frischer, MD, PhD
Principal Investigator
Medical University of Vienna