Predicting Pathological Complete Response of Rectal Cancer With Magnetic Resonance(MR) Radiomics
Completed
- Conditions
- Locally Advanced Rectal Cancer
- Interventions
- Diagnostic Test: pelvic MR examination
- Registration Number
- NCT03238885
- Lead Sponsor
- Sun Ying-Shi
- Brief Summary
This study plans to construct a MR radiomics model for predicting pathological complete response(pCR) to neoadjuvant chemoradiotherapy(CRT) in locally advanced rectal cancer(LARC) patients.
- Detailed Description
We propose to develop and validate a radiomics model for individualized pCR evaluation after CRT in patients with LARC. We plan to use both pre- and post-CRT MRI data to construct the predictive radiomics model for evaluating if LARC patients achieve pCR after CRT. The ultimate aim is to select appropriate LARC patients for omission of surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 538
Inclusion Criteria
- pathologically proved rectal cancer
- locally advanced rectal cancer (≥T3 or N+)
- a distance less than 12cm between the lower edge of tumor and the anal margin
- no evidence of distant metastases
- no prior anti-cancer therapy before treatment
- scheduled to receive preoperative CRT
Exclusion Criteria
- history or concurrent of other malignancy
- incomplete preoperative CRT
- failed to receive surgery or unavailable pCR assessment
- poor quality of MR images for measurement
- patient quit
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description LARC-CRT pelvic MR examination LARC patients who will receive neoadjuvant CRT before surgical resection.
- Primary Outcome Measures
Name Time Method Pathological complete response(pCR) within one week after surgery Pathological complete response was defined as the absence of viable tumor cells in the primary tumor and lymph nodes.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Beijing Cancer Hospital
🇨🇳Beijing, Beijing, China