Radiomic Analysis for Predicting Treatment Response and Clinical Outcomes in Malignancies

Active, not recruiting

• Conditions: Breast Cancer; Brain Cancer; Gynecologic Cancer; Head and Neck Cancer

• Registration Number: NCT05170087
• Lead Sponsor: Sunnybrook Health Sciences Centre

Brief Summary

In this study, the investigators aim to undertake a retrospective analysis of CT and MRI scans for patients undergoing radiation treatment to develop radiomic signatures to predict treatment response and clinical outcomes.

Detailed Description

Imaging in oncology has widespread application with modalities like ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) having a well-established role particularly in diagnosis, staging, assessment of treatment response, and surveillance. With the applications of radiomics in oncology, the potential of imaging as a non-invasive biomarker in treatment response, as well as genotypic characterization, has been recognized. Radiomics has the potential to tailor way towards precision oncology with the development of biomarkers that can guide personalized treatments. In this study, the investigators aim at developing CT and MRI radiomic signatures as potential biomarkers to predict treatment response and clinical outcomes for patients treated with radiation having breast, brain, head and neck, and gynecological malignancies.

Study Timeline

• Study Start: 2020-03-02
• Study First Submitted: 2021-11-23
• Study First Submitted QC: 2021-12-10
• Study First Posted: 2021-12-27
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-17
• Last Update Posted: 2023-04-19
• Primary Completion: 2025-03
• Study Completion: 2025-03

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

• Breast, head and neck, brain, and gynecological malignancies
• Treated with radiation at Odette Cancer Centre between 2010 and 2019

Exclusion Criteria

• N/A

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Development of imaging biomarkers in predicting treatment response for breast, brain, head-neck, and gynecological malignancies	1 year	Development of imaging biomarkers in predicting treatment response
Development of imaging biomarkers in predicting clinical outcomes (survival/toxicity) for breast, brain, head-neck, and gynecological malignancies	1 year	Development of imaging biomarkers in predicting clinical outcomes (survival/toxicity)

Trial Locations

Locations (1)

Sunnybrook Health Sciences Centre; 🇨🇦 Toronto, Ontario, Canada