PET CT Re-Planning NSCLC (4DCT-PET)

Not Applicable

Completed

• Conditions: Lung Cancer; Non-Small Cell Lung Cancer

• Registration Number: NCT03403127
• Lead Sponsor: University Health Network, Toronto

Brief Summary

This study will see whether the addition of more frequent planning CTs during the course of radiation, and of Positron Emission Tomography (PET), a diagnostic test similar to CT, prior to and during a course of radiation may provide information that could potentially be used during the treatment to improve the initial radiation plan.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-05-20
• Primary Completion: 2013-03-25
• Study First Submitted: 2018-01-11
• Study First Submitted QC: 2018-01-11
• Study First Posted: 2018-01-18
• Study Completion: 2020-04-28
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-13
• Last Update Posted: 2020-08-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Age equal to or more than 18 years old
• Patients with NSCLC consenting for radiotherapy to the primary tumor and / or mediastinal / hilar lymph nodes. Prescription doses should be 60Gy or higher.
• Chemo-RT patients of any stage of NSCLC
• Patients with a measurable tumor on CT scan.
• Patients who are able to lie supine for two consecutive 25 minutes sessions.

Exclusion Criteria

• Trimodality patients who will have surgery within 2 months post RT
• Previous radiotherapy to intended treatment volumes.
• Patients with recurrent disease
• Active malignancy other than lung cancer
• Pregnancy
• Failure to provide written informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
GTV volumes	3 months post RT treatment	The ratio of the GTV volumes defined using FDG PET (GTVPET) planning scans
GTV Volumes	7 weeks post RT Treatment	The ratio of the GTV volumes defined using FDG PET (GTVPET) planning scans