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临床试验/NCT02420483
NCT02420483Unknown不适用

Lung Ventilation During Cardiopulmonary Resuscitation

University of Thessaly2 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2015年12月最近更新:
适应症

试验速览

阶段
不适用
入组人数
25
试验地点
2
主要终点
Tidal volume during cardiopulmonary resuscitation

研究概览

简要总结

The authors to measure passive tidal volumes generated during external chest compressions in order to determine whether chest compressions alone without any mechanical ventilatory support in cardiopulmonary resuscitation can provide adequate ventilation. The authors will study 25 volunteers who meet the following inclusion criteria: age 18-55 years, ASA I-II, candidates for surgical operation, who will receive general anesthesia. Patients who will be operated in the chest, who present musculoskeletal diseases, cardiopulmonary or vascular acute or chronic diseases, who had history of pneumothorax, of thromboembolism, osteoporosis, menopause, history of current rib or sternal or clavicle fractures, will be excluded. All eligible patients will enter the study and will receive general anesthesia and intubation according to treating doctors' decision.

Patients will be ventilated mechanically for 5 minutes to establish stable conditions. A pneumotachograph will be then connected to the ventilatory circuit so that respiratory efforts (volume, airway pressure and flow) can be continuously monitored at real time.

An esophageal catheter will be then inserted to monitor esophageal pressures and to provide data for lung mechanics calculation. Following the above procedures and before any surgical procedure, chest compressions will be performed to the patient by a senior anesthesiologist according to ERC guidelines of 2010 for 30 seconds.

Following chest compressions, patients will be evaluated for possible complications and after the establishment of stable conditions surgical procedures will follow. After the end of the surgical operation clinical and chest ultrasound evaluation will be performed.

Written inform consent will be obtained by all patients before procedures.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 55 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • age 18-55 years
  • candidates for surgical operation who will receive general anesthesia

排除标准

  • surgical operation in the chest
  • musculoskeletal diseases
  • cardiopulmonary or vascular acute or chronic diseases
  • history of pneumothorax
  • thromboembolism
  • osteoporosis menopause history of current rib or sternal or clavicle fractures

结局指标

主要结局

Tidal volume during cardiopulmonary resuscitation

时间窗: 30 seconds

Tidal volume will be assessed by a pneumotachograph (Hans Rudolf USA)

次要结局

  • Esophageal pressures during cardiopulmonary resuscitation(30 seconds)
  • Lung compliance before and at the end of cardiopulmonary resuscitation(30 seconds)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

DEMOSTHENES MAKRIS

ASS PROFESSOR CRITICAL CARE MEDICINE

University of Thessaly

研究点 (2)

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