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Clinical Trials/NCT02420483
NCT02420483
Unknown
N/A

Lung Ventilation During Cardiopulmonary Resuscitation

University of Thessaly1 site in 1 country25 target enrollmentDecember 2015

Overview

Phase
N/A
Intervention
Not specified
Conditions
Ventilation During Cardiopulmonary Resuscitation
Sponsor
University of Thessaly
Enrollment
25
Locations
1
Primary Endpoint
Tidal volume during cardiopulmonary resuscitation
Last Updated
9 years ago

Overview

Brief Summary

The authors to measure passive tidal volumes generated during external chest compressions in order to determine whether chest compressions alone without any mechanical ventilatory support in cardiopulmonary resuscitation can provide adequate ventilation. The authors will study 25 volunteers who meet the following inclusion criteria: age 18-55 years, ASA I-II, candidates for surgical operation, who will receive general anesthesia. Patients who will be operated in the chest, who present musculoskeletal diseases, cardiopulmonary or vascular acute or chronic diseases, who had history of pneumothorax, of thromboembolism, osteoporosis, menopause, history of current rib or sternal or clavicle fractures, will be excluded. All eligible patients will enter the study and will receive general anesthesia and intubation according to treating doctors' decision.

Patients will be ventilated mechanically for 5 minutes to establish stable conditions. A pneumotachograph will be then connected to the ventilatory circuit so that respiratory efforts (volume, airway pressure and flow) can be continuously monitored at real time.

An esophageal catheter will be then inserted to monitor esophageal pressures and to provide data for lung mechanics calculation. Following the above procedures and before any surgical procedure, chest compressions will be performed to the patient by a senior anesthesiologist according to ERC guidelines of 2010 for 30 seconds.

Following chest compressions, patients will be evaluated for possible complications and after the establishment of stable conditions surgical procedures will follow. After the end of the surgical operation clinical and chest ultrasound evaluation will be performed.

Written inform consent will be obtained by all patients before procedures.

Registry
clinicaltrials.gov
Start Date
December 2015
End Date
December 2018
Last Updated
9 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

DEMOSTHENES MAKRIS

ASS PROFESSOR CRITICAL CARE MEDICINE

University of Thessaly

Eligibility Criteria

Inclusion Criteria

  • age 18-55 years
  • candidates for surgical operation who will receive general anesthesia

Exclusion Criteria

  • surgical operation in the chest
  • musculoskeletal diseases
  • cardiopulmonary or vascular acute or chronic diseases
  • history of pneumothorax
  • thromboembolism
  • osteoporosis menopause history of current rib or sternal or clavicle fractures

Outcomes

Primary Outcomes

Tidal volume during cardiopulmonary resuscitation

Time Frame: 30 seconds

Tidal volume will be assessed by a pneumotachograph (Hans Rudolf USA)

Secondary Outcomes

  • Esophageal pressures during cardiopulmonary resuscitation(30 seconds)
  • Lung compliance before and at the end of cardiopulmonary resuscitation(30 seconds)

Study Sites (1)

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