The effects of remifentanil on maternal hemodynamic, oxidative stress and neonatal outcome: comparison of two dosing regimens used during the induction-delivery period of caesarean section performed under general anesthesia
Phase 4
- Conditions
- Hemodynamic and oxidative stress response to anesthesia and surgery during elective caesarean section
- Registration Number
- DRKS00015114
- Lead Sponsor
- Clinic of Gynaecology and Obstetrics University Clinical Center Nis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 60
Inclusion Criteria
Patients ASA I and II status, scheduled for elective caesarean section in general anesthesia who have given written informed consent.
All patients refuse or have absolute/relative medical contraindications to regional anesthesia.
Exclusion Criteria
Exclusion criteria are: known cardiac, respiratory, neurologic, renal, endocrine, psychiatric disorders, history of drug or alcohol abuse, morbid obesity, preeclampsia, predicted difficult airway management, active labor, known fetal congenital abnormalities or signs of fetal compromise.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Our main goal is to compare the changes of maternal blood pressure, heart rate values measured after endotracheal intubation, skin incision, peritoneal incision and delivery during caesarean cestion between groups that were under different remifentanil dosing regimens and to investigate the effect of those regimens on oxidative stress.
- Secondary Outcome Measures
Name Time Method We also compare neonatal outcome between groups (Apgar scores at 1st and 5th minute, HR, oxygen saturation, the need for resuscitative measures and umbilical venous and arterial blood gas values).