Spinal morphine in patients with hip fractures to reduce delirium

Maasstad Hospital Rotterdam0 个研究点目标入组 364 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•- Femur fracture
•- Scheduled for surgery
•- Spinal anesthesia

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•- Contraindications for spinal anesthesia:
•o Patients’ refusal
•o Coagulation disorders (clopidogrel, INR>1.8, anticoagulation with nadroparine (>100 aXa-IE/kg), heparine (APTT> 30 sec), recent use of a Direct Oral Anticoagulant, as stated in the guideline Neuraxisblokkade en antistolling” by the Dutch Society of Anesthesiology).
•o Aortic Valve Stenosis of AVA < 1.0 cm2
•o Lumbar malformations (local inflammation, lumbar osteosynthesis material, meningocele, tethered cord)
•- Inability to retrieve cerebrospinal fluid by lumbar puncture.
•- Contra-indications for intrathecal morphine:
•o Chronic opioid or benzodiazepine use (>1 month daily use).
•- Allergies to amide-type local anesthetics and morphine.
•- Patients who are incapable of making decisions regarding anesthesia and no legal representative is available.

发起方

Maasstad Hospital Rotterdam